TY - JOUR
T1 - Long term regulation of cardiac l-type calcium channel by small G proteins
AU - Magyar, J.
AU - Jenes, Á
AU - Kistamás, K.
AU - Ruzsnavszky, F.
AU - Nánási, P. P.
AU - Satin, J.
AU - Szentandrássy, N.
AU - Bányász, T.
PY - 2011/8
Y1 - 2011/8
N2 - Calcium ions are crucial elements of excitation-contraction coupling in cardiac myocytes. The intracellular Ca 2+ concentration changes continously during the cardiac cycle, but the Ca 2+ entering to the cell serves as an intracellular second messenger, as well. The Ca 2+ as a second messenger influences the activity of many intracellular signalling pathways and regulates gene expression. In cardiac myocytes the major pathway for Ca 2+ entry into cells is L-type calcium channel (LTCC). The precise control of LTCC function is essential for maintaining the calcium homeostasis of cardiac myocytes. Dysregulation of LTCC may result in different diseases like cardiac hypertrophy, arrhytmias, heart failure. The physiological and pathological structural changes in the heart are induced in part by small G proteins. These proteins are involved in wide spectrum of cell biological functions including protein transport, regulation of cell proliferation, migration, apoptosis, and cytoskeletal rearrangement. Understanding the crosstalk between small G proteins and LTCC may help to understand the pathomechanism of different cardiac diseases and to develop a new generation of genetically-encoded Ca 2+ channel inhibitors.
AB - Calcium ions are crucial elements of excitation-contraction coupling in cardiac myocytes. The intracellular Ca 2+ concentration changes continously during the cardiac cycle, but the Ca 2+ entering to the cell serves as an intracellular second messenger, as well. The Ca 2+ as a second messenger influences the activity of many intracellular signalling pathways and regulates gene expression. In cardiac myocytes the major pathway for Ca 2+ entry into cells is L-type calcium channel (LTCC). The precise control of LTCC function is essential for maintaining the calcium homeostasis of cardiac myocytes. Dysregulation of LTCC may result in different diseases like cardiac hypertrophy, arrhytmias, heart failure. The physiological and pathological structural changes in the heart are induced in part by small G proteins. These proteins are involved in wide spectrum of cell biological functions including protein transport, regulation of cell proliferation, migration, apoptosis, and cytoskeletal rearrangement. Understanding the crosstalk between small G proteins and LTCC may help to understand the pathomechanism of different cardiac diseases and to develop a new generation of genetically-encoded Ca 2+ channel inhibitors.
KW - Calcium channel
KW - Heart
KW - Small G protein
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U2 - 10.2174/092986711796642436
DO - 10.2174/092986711796642436
M3 - Article
C2 - 21774757
AN - SCOPUS:80051997255
SN - 0929-8673
VL - 18
SP - 3714
EP - 3719
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 24
ER -