Long-term survival of neural transplants to senescence in rats

Michael J. Russell, Vijaya K. Vijayan, Robert B. Gibbs, James W. Geddes, Carl H. Jacobson, Carl W. Cotman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A critical issue for clinical and research applications of transplant techniques is the long-term survival of transplanted tissue and its effect on the host brain. In this study, entorhinal cortices from donor embryos were transplanted into the lesioned angular bundle of juvenile male Sprague-Dawley rats. Animals were maintained for 2 years and then sacrificed for histological and histochemical examinations. The results indicate that entorhinal transplants survive to old age and that both the host and transplant tissues maintain morphological features consistent with those of short-term neural grafts. An unexpected finding of this experiment was the persistence in the transplanted tissue and adjacent host cortex of a pattern of AChE staining which is typical of early postnatal development.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalExperimental Neurology
Issue number2
StatePublished - May 1990

Bibliographical note

Funding Information:
This work was supported in part by grants from the J. Howard Foundation and the National Institute of Aging Training AGO0096 (C.W.C).

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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