Longitudinal Examination of Prenatal Tobacco Switching Behaviors and Birth Outcomes, Including Electronic Nicotine Delivery System (ENDS) and Dual Use

Kristin Ashford, Andrea McCubbin, Janine Barnett, Lisa M. Blair, Feitong Lei, Heather Bush, Alison Breland

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: In the US, approximately 8% of pregnant women smoke, and 5–11.9% currently use ENDS products. The health effects of ENDS use are debated; however, most contain nicotine which is known to cause adverse perinatal outcomes. Studies have shown adult ENDS users significantly alter use behaviors over time (switch to conventional cigarettes-only or dual use) thus complicating efforts to examine health effects of ENDS use. The purpose of this study was to describe switching behaviors and associated birth outcomes among infants of women using conventional cigarettes only, ENDS-only, or both. Methods: This was a multisite, longitudinal study of biologically confirmed perinatal tobacco users, with nicotine product use assessed each trimester. For the purpose of analysis, participants were defined as switchers, no-switchers, or quitters. Birth outcomes were abstracted from electronic medical records. Analysis included descriptive statistics, linear and multivariate logistic regression adjusted for age, preterm birth, smoking behavior in the first trimester, and an interaction between smoking switching behavior and smoking behavior in the first trimester. Analysis was conducted using SAS v9.4 with significance determined as p < 0.05. Results: At enrollment, 48.6% of participants used only conventional cigarettes, 41.7% were dual users, and 10% used ENDS-only. While almost two-thirds of participants used the same tobacco product throughout pregnancy, 26% reported switching behaviors that were complex and not easily clustered. No differences were found in birth outcomes between switchers and no-switchers; however, a difference emerged in birth weight between no-switchers and quitters. Discussion: Given the limited data on health effects of ENDS use, and the known harmful consequences of perinatal nicotine use, capturing and classifying product switching behaviors is imperative to inform public health, and remains a challenge requiring further research.

Original languageEnglish
Pages (from-to)1175-1181
Number of pages7
JournalMaternal and Child Health Journal
Volume25
Issue number8
DOIs
StatePublished - Aug 2021

Bibliographical note

Funding Information:
The project was also supported by the NIH National Center for Advancing Translational Sciences through Grant No. UL1TR001998, through use of the REDCap research project database through the University of Kentucky Clinical and Translational Research Center.

Funding Information:
This work was supported by the National Institute on Drug Abuse at the National Institutes of Health under Award Number R01DA040694-01 to K. Ashford, and in part by the NIH National Center for Advancing Translational Sciences through Grant No. UL1TR001998. Additionally, Dr. Breland’s effort (co-author) is supported in part by the National Institute on Drug Abuse of the National Institutes of Health under Award Number U54DA036105 and the Center for Tobacco Products of the U.S. Food and Drug Administration. The content is solely the responsibility of the authors and does not necessarily represent the views of the NIH or the FDA.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Birth outcomes
  • ENDS
  • Electronic cigarettes
  • Pregnancy
  • Switching behaviors

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Public Health, Environmental and Occupational Health

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