Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease

C. D. Smith, R. J. Kryscio, F. A. Schmitt, M. A. Lovell, L. X. Blonder, W. S. Rayens, A. H. Andersen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose. The authors sought to determine whether known alterations of brain function in normal individuals who are at high risk for Alzheimer's disease (AD) worsen or stay the same after a significant interval of time. Methods, The authors used functional magnetic resonance imaging (fMRI) to observe cortical activation during confrontation naming in 14 women with high AD risk and 10 with low risk, based on family history and apolipoprctein-E4 allele status. They repeated the identical scan protocol in the same patients after 4 years. Results. fMRI activation in high-AD-risk participants was found to be further diverged from that of their low-AD-risk counterparts over this period. Conclusion. fMRI may report on the presence and progression of neuropathology in the ventral temporal cortex or in functionally connected regions in presymptomatic AD.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalJournal of Neuroimaging
Issue number3
StatePublished - Jul 2005


  • Alzheimer's disease
  • Apolipoprotein-E
  • Functional magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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