Low bone volume - A risk factor for coronary calcifications in hemodialysis patients

Teresa Adragao, Johann Herberth, Marie Claude Monier-Faugere, Adam J. Branscum, Anibal Ferreira, Joao M. Frazao, Jose Dias Curto, Hartmut H. Malluche

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Background and objectives: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. Design, setting, participants, & measurements: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. Results: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. Conclusions: Low bone volume is associated with increased coronary calcifications in patients on HD.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Issue number2
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


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