TY - JOUR
T1 - Low bone volume - A risk factor for coronary calcifications in hemodialysis patients
AU - Adragao, Teresa
AU - Herberth, Johann
AU - Monier-Faugere, Marie Claude
AU - Branscum, Adam J.
AU - Ferreira, Anibal
AU - Frazao, Joao M.
AU - Curto, Jose Dias
AU - Malluche, Hartmut H.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Background and objectives: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. Design, setting, participants, & measurements: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. Results: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. Conclusions: Low bone volume is associated with increased coronary calcifications in patients on HD.
AB - Background and objectives: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. Design, setting, participants, & measurements: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. Results: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. Conclusions: Low bone volume is associated with increased coronary calcifications in patients on HD.
UR - https://www.scopus.com/pages/publications/66849101767
UR - https://www.scopus.com/pages/publications/66849101767#tab=citedBy
U2 - 10.2215/CJN.01870408
DO - 10.2215/CJN.01870408
M3 - Article
C2 - 19158372
AN - SCOPUS:66849101767
SN - 1555-9041
VL - 4
SP - 450
EP - 455
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 2
ER -