TY - JOUR
T1 - Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy
AU - Horbinski, Craig
AU - Dillon, Donita
AU - Pittman, Thomas
PY - 2011/6
Y1 - 2011/6
N2 - The biological behavior of pediatric gliomas and embryonal tumors can be highly variable. A few case reports have described differentiation of primitive neuroectodermal tumors (PNETs) and medulloblastomas, presumably induced by adjuvant chemotherapy and/or radiation. Herein we describe a case of a congenital supratentorial high-grade tumor with astrocytic features that, after near-total surgical resection, was not treated with adjuvant therapies. Thirteen years later the patient presented with recurrent tumor at the original surgical site. The recurrent tumor had completely different morphology compared to the original, with evidence of ganglion cell differentiation and changes more reminiscent of a low-grade pleomorphic xanthoastrocytoma. To the authors' knowledge, this is the first documented case of an untreated high-grade pediatric tumor that spontaneously differentiated into a low grade tumor. The clinical and biological implications of this are briefly discussed.
AB - The biological behavior of pediatric gliomas and embryonal tumors can be highly variable. A few case reports have described differentiation of primitive neuroectodermal tumors (PNETs) and medulloblastomas, presumably induced by adjuvant chemotherapy and/or radiation. Herein we describe a case of a congenital supratentorial high-grade tumor with astrocytic features that, after near-total surgical resection, was not treated with adjuvant therapies. Thirteen years later the patient presented with recurrent tumor at the original surgical site. The recurrent tumor had completely different morphology compared to the original, with evidence of ganglion cell differentiation and changes more reminiscent of a low-grade pleomorphic xanthoastrocytoma. To the authors' knowledge, this is the first documented case of an untreated high-grade pediatric tumor that spontaneously differentiated into a low grade tumor. The clinical and biological implications of this are briefly discussed.
KW - Astrocytoma
KW - Ganglioglioma
KW - Pediatric
KW - Pleomorphic xanthoastrocytoma
KW - PNET
UR - http://www.scopus.com/inward/record.url?scp=79957554845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957554845&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1789.2010.01156.x
DO - 10.1111/j.1440-1789.2010.01156.x
M3 - Article
C2 - 20880322
AN - SCOPUS:79957554845
SN - 0919-6544
VL - 31
SP - 286
EP - 291
JO - Neuropathology
JF - Neuropathology
IS - 3
ER -