Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Edward J. Goetzl; Adam Boxer; Janice B. Schwartz; Erin L. Abner; Ronald C. Petersen; Bruce L. Miller; Olga D. Carlson; Maja Mustapic; Dimitrios Kapogiannis

doi:10.1002/acn3.211

Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald C. Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic, Dimitrios Kapogiannis

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Original language	English
Pages (from-to)	769-773
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	2
Issue number	7
DOIs	https://doi.org/10.1002/acn3.211
State	Published - Jul 2015

Bibliographical note

Publisher Copyright:
© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1002/acn3.211

Cite this

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abstract = "Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.",

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AU - Petersen, Ronald C.

AU - Miller, Bruce L.

AU - Carlson, Olga D.

AU - Mustapic, Maja

AU - Kapogiannis, Dimitrios

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Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Abstract

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