Low serum insulin-like growth factor 1 (IGF-1): A significant association with prostate cancer

R. Baffa, K. Reiss, E. A. El-Gabry, J. Sedor, M. L. Moy, D. Shupp-Byrne, S. E. Strup, W. W. Hauck, R. Baserga, L. G. Gomella

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Purpose: Insulin-like growth factor 1 (IGF-1) is an important mitogenic and antiapoptotic peptide that affects the proliferation of normal and malignant cells. Contradictory reports on the association between serum IGF-1 level and prostate cancer have been highlighted in the recent literature. The purpose of this study was to investigate the relation between serum levels of IGF-1 and prostate cancer. Materials and Methods: We analyzed a population of 57 patients who underwent radical prostatectomy (RP) for adenocarcinoma. Serum samples were collected before RP (TO), 6 months after RP (T6), and from 39 age-matched controls. IGF- 1 levels were determined by the active IGF-1 Elisa kit (Diagnostic Systems Laboratories, Inc.). Parallel samples were evaluated for prostate-specific antigen (PSA) levels. Data between groups were analyzed using Welch's t-test and levels before RP and after 6 months were compared by paired t-test. Results: The normal mean serum IGF-1 for case patients at TO (124.6 ± 58.2 ng/mL) was significantly lower than the control subjects (157.5 ± 70.8 ng/mL; p = .0192). The normal mean serum IGF-1 for case patients at TO (124.91 ± 58.6 ng/mL) also was significantly lower when it was compared with the T6 group (148.49 ± 57.2 ng/mL; p = .0056). No association was found between IGF-1 and PSA blood levels, or IGF-1 and patient weight (p = 0.2434). An inverse relation between IGF-1 levels and age in the normal controls (p = .0041) was observed. Conclusion: Findings of this study indicate a significant association between low serum levels of IGF-1 and prostate cancer.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalTechniques in Urology
Volume6
Issue number3
StatePublished - 2000

Keywords

  • Insulin-like growth factor 1
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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