LruA and LruB antibodies in sera of humans with leptospiral uveitis

Ashutosh Verma, S. R. Rathinam, C. Gowri Priya, V. R. Muthukkaruppan, Brian Stevenson, John F. Timoney

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that crossreacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.

Original languageEnglish
Pages (from-to)1019-1023
Number of pages5
JournalClinical and Vaccine Immunology
Volume15
Issue number6
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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