TY - JOUR
T1 - LruA and LruB antibodies in sera of humans with leptospiral uveitis
AU - Verma, Ashutosh
AU - Rathinam, S. R.
AU - Priya, C. Gowri
AU - Muthukkaruppan, V. R.
AU - Stevenson, Brian
AU - Timoney, John F.
PY - 2008/6
Y1 - 2008/6
N2 - Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that crossreacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.
AB - Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that crossreacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.
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U2 - 10.1128/CVI.00203-07
DO - 10.1128/CVI.00203-07
M3 - Article
C2 - 18400972
AN - SCOPUS:47049106452
SN - 1556-6811
VL - 15
SP - 1019
EP - 1023
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 6
ER -