Abstract
Anti-Lyb-5.1 serum contains antibodies against two different B cell surface antigenic determinants, Lyb-5.1 and Lyb-7.1, which are defined in cytotoxicity and functional tests, respectively. The antibody against Lyb-7.1 is identified by its ability to specifically inhibit in vitro primary antibody responses to TNP-Ficoll. Anti-Lyb-5.1 serum can be made monospecific for anti-Lyb-7.1 activity by absorption with spleen cells from AL/N mice which have been typed as Lyb-5.1 +, Lyb-7.1 -. Lyb-5.1 and Lyb-7.1 are each under control of one or one set of closely linked genes. The loci specifying Lyb-5.1 and Lyb-7.1 are not linked to each other nor to M1s and H-2 loci. However, the gene controlling the expression of Lyb-7.1 is linked to the genes coding for the constant region of immunoglobulin heavy chains.
| Original language | English |
|---|---|
| Pages (from-to) | 2279-2285 |
| Number of pages | 7 |
| Journal | Journal of Immunology |
| Volume | 122 |
| Issue number | 6 |
| State | Published - 1979 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology