Macrocycles used as models to probe the interaction of a fatty acid derivative with its natural receptor

Shigeru Watanabe; Mara Tsesarskaja; Bert C. Lynn; Jeanette C. Hernandez; Tianbao Lu; Qi Li; Jeffrey I. Gordon; George W. Gokel

doi:10.1351/pac199365030467

Macrocycles used as models to probe the interaction of a fatty acid derivative with its natural receptor

Shigeru Watanabe, Mara Tsesarskaja, Bert C. Lynn, Jeanette C. Hernandez, Tianbao Lu, Qi Li, Jeffrey I. Gordon, George W. Gokel

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A macrocycle-based receptor system was developed to study the interactions of fatty acids and their coenzyme A derivatives with the binding site of a receptor molecule. Although the specific compounds failed to fulfill the purpose of their design, interesting information about ammonium ion interactions with azacrowns was obtained by use of fast atom bombardment mass spectrometry.

Original language	English
Pages (from-to)	467-472
Number of pages	6
Journal	Pure and Applied Chemistry
Volume	65
Issue number	3
DOIs	https://doi.org/10.1351/pac199365030467
State	Published - Jan 1 1993

Bibliographical note

Funding Information:
We thank the NIH for grants (GM 36262 to GWG, AI 27179 and A3 30188 to JIG and GWG) that supported this work.

Funding

We thank the NIH for grants (GM 36262 to GWG, AI 27179 and A3 30188 to JIG and GWG) that supported this work.

Funders	Funder number
National Institutes of Health (NIH)	GM 36262, A3 30188, AI 27179
National Institutes of Health (NIH)

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1351/pac199365030467

Cite this

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abstract = "A macrocycle-based receptor system was developed to study the interactions of fatty acids and their coenzyme A derivatives with the binding site of a receptor molecule. Although the specific compounds failed to fulfill the purpose of their design, interesting information about ammonium ion interactions with azacrowns was obtained by use of fast atom bombardment mass spectrometry.",

author = "Shigeru Watanabe and Mara Tsesarskaja and Lynn, {Bert C.} and Hernandez, {Jeanette C.} and Tianbao Lu and Qi Li and Gordon, {Jeffrey I.} and Gokel, {George W.}",

note = "Funding Information: We thank the NIH for grants (GM 36262 to GWG, AI 27179 and A3 30188 to JIG and GWG) that supported this work.",

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AU - Watanabe, Shigeru

AU - Tsesarskaja, Mara

AU - Lynn, Bert C.

AU - Hernandez, Jeanette C.

AU - Lu, Tianbao

AU - Li, Qi

AU - Gordon, Jeffrey I.

AU - Gokel, George W.

N1 - Funding Information: We thank the NIH for grants (GM 36262 to GWG, AI 27179 and A3 30188 to JIG and GWG) that supported this work.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - A macrocycle-based receptor system was developed to study the interactions of fatty acids and their coenzyme A derivatives with the binding site of a receptor molecule. Although the specific compounds failed to fulfill the purpose of their design, interesting information about ammonium ion interactions with azacrowns was obtained by use of fast atom bombardment mass spectrometry.

AB - A macrocycle-based receptor system was developed to study the interactions of fatty acids and their coenzyme A derivatives with the binding site of a receptor molecule. Although the specific compounds failed to fulfill the purpose of their design, interesting information about ammonium ion interactions with azacrowns was obtained by use of fast atom bombardment mass spectrometry.

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IS - 3

ER -

Macrocycles used as models to probe the interaction of a fatty acid derivative with its natural receptor

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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