Macrophage regulation of muscle regrowth from disuse in aging

Paul T. Reidy; Esther E. Dupont-Versteegden; Micah J. Drummond

doi:10.1249/JES.0000000000000201

Macrophage regulation of muscle regrowth from disuse in aging

Paul T. Reidy, Esther E. Dupont-Versteegden, Micah J. Drummond

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.

Original language	English
Pages (from-to)	246-250
Number of pages	5
Journal	Exercise and Sport Sciences Reviews
Volume	47
Issue number	4
DOIs	https://doi.org/10.1249/JES.0000000000000201
State	Published - Oct 1 2019

Bibliographical note

Publisher Copyright:
© Lippincott Williams & Wilkins.

Keywords

aging
immune cells
injury
physical inactivity
polarization
rehabilitation

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000201

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abstract = "Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.",

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AU - Dupont-Versteegden, Esther E.

AU - Drummond, Micah J.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

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AB - Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.

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KW - immune cells

KW - injury

KW - physical inactivity

KW - polarization

KW - rehabilitation

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Macrophage regulation of muscle regrowth from disuse in aging

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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