Magnetic iron oxide nanoparticles for disease detection and therapy

Sheng Tong, Haibao Zhu, Gang Bao

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Magnetic iron oxide nanoparticles (MIONs) are among the first generation of nanomaterials that have advanced to clinic use. A broad range of biomedical techniques have been developed by combining the versatile nanomagnetism of MIONs with various forms of applied magnetic fields. MIONs can generate imaging contrast and provide mechanical/thermal energy in vivo in response to an external magnetic field, a special feature that distinguishes MIONs from other nanomaterials. These properties offer unique opportunities for nanomaterials engineering in biomedical research and clinical interventions. The past few decades have witnessed the evolution of the applications of MIONs from conventional drug delivery and hyperthermia to the regulation of molecular and cellular processes in the body. Here we review the most recent development in this field, including clinical studies of MIONs and the emerging techniques that may contribute to future innovation in medicine.

Original languageEnglish
Pages (from-to)86-99
Number of pages14
JournalMaterials Today
Volume31
DOIs
StatePublished - Dec 2019

Bibliographical note

Funding Information:
This work was supported by the Cancer Prevention and Research Institute of Texas ( RR140081 to G.B.) and the National Institutes of Health ( R01EB026893 to S.T.).

Funding Information:
This work was supported by the Cancer Prevention and Research Institute of Texas (RR140081 to G.B.) and the National Institutes of Health (R01EB026893 to S.T.).

Publisher Copyright:
© 2019 Elsevier Ltd

ASJC Scopus subject areas

  • Materials Science (all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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