TY - JOUR
T1 - Magnetic nanoparticles and nanocomposites for remote controlled therapies
AU - Hauser, Anastasia K.
AU - Wydra, Robert J.
AU - Stocke, Nathanael A.
AU - Anderson, Kimberly W.
AU - Hilt, J. Zach
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/12/10
Y1 - 2015/12/10
N2 - This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.
AB - This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.
KW - Magnetic nanoparticles
KW - Nanocomposites
KW - Remote controlled drug delivery
UR - http://www.scopus.com/inward/record.url?scp=84947219857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947219857&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2015.09.039
DO - 10.1016/j.jconrel.2015.09.039
M3 - Article
C2 - 26407670
AN - SCOPUS:84947219857
SN - 0168-3659
VL - 219
SP - 76
EP - 94
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -