Magnetic nanoparticles and nanocomposites for remote controlled therapies

Anastasia K. Hauser, Robert J. Wydra, Nathanael A. Stocke, Kimberly W. Anderson, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

Original languageEnglish
Pages (from-to)76-94
Number of pages19
JournalJournal of Controlled Release
Volume219
DOIs
StatePublished - Dec 10 2015

Bibliographical note

Funding Information:
AKH, RJW, and NAS were partially supported by Grant Number R25CA153954 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. Additionally, AKH was partially supported by the National Science Foundation Graduate Research Fellowship Program Grant No. DGE-1247392. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Keywords

  • Magnetic nanoparticles
  • Nanocomposites
  • Remote controlled drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

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