Magnetic nanoparticles: reactive oxygen species generation and potential therapeutic applications

Trang Mai, J. Zach Hilt

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Magnetic nanoparticles have been demonstrated to produce reactive oxygen species (ROS), which play a major role in various cellular pathways, via Fenton and Haber-Weiss reaction. ROS act as a double-edged sword inside the body. At normal conditions, the generation of ROS is in balance with their elimination by scavenger systems, and they can promote cell proliferation as well as differentiation. However, at an increased level, they can cause damages to protein, lead to cellular apoptosis, and contribute to many diseases including cancer. Many recent studies proposed a variety of strategies to either suppress toxicity of ROS generation or exploit the elevated ROS levels for cancer therapy.

Original languageEnglish
Article number253
JournalJournal of Nanoparticle Research
Volume19
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Antioxidant
  • Biomedicine
  • Magnetic nanoparticles
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Atomic and Molecular Physics, and Optics
  • Modeling and Simulation
  • Materials Science (all)
  • Condensed Matter Physics

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