Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi; Lee R. Wiederhold; Gargi Roy; Rabindra Roy; Arun Jaiswal; Kishor K. Bhakat; Sankar Mitra; Tapas K. Hazra

doi:10.1016/S0300-483X(03)00289-0

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi, Lee R. Wiederhold, Gargi Roy, Rabindra Roy, Arun Jaiswal, Kishor K. Bhakat, Sankar Mitra, Tapas K. Hazra

Toxicology and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

185 Scopus citations

Abstract

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

Original language	English
Pages (from-to)	43-65
Number of pages	23
Journal	Toxicology
Volume	193
Issue number	1-2
DOIs	https://doi.org/10.1016/S0300-483X(03)00289-0
State	Published - Nov 15 2003

Bibliographical note

Funding Information:
We would like to thank Dr. M. Park for his gift of FEN1 antibody, and Drs. D. Brown and M. Greenberg for their insights. We are grateful for Dr. D. Konkel for his editorial help, and Ms. W. Smith for her secretarial assistance. The work described in this review from the authors’ laboratories was supported by USPHS grants CA53791, CA81063, CA98664, ES08457, EAP01CA92, and Department of Energy grant (DE-FG-03-00ER63041).

Funding

We would like to thank Dr. M. Park for his gift of FEN1 antibody, and Drs. D. Brown and M. Greenberg for their insights. We are grateful for Dr. D. Konkel for his editorial help, and Ms. W. Smith for her secretarial assistance. The work described in this review from the authors’ laboratories was supported by USPHS grants CA53791, CA81063, CA98664, ES08457, EAP01CA92, and Department of Energy grant (DE-FG-03-00ER63041).

Funders	Funder number
Michigan State University-U.S. Department of Energy (MSU-DOE) Plant Research Laboratory	DE-FG-03-00ER63041
National Childhood Cancer Registry – National Cancer Institute	R56CA098664
U.S. Public Health Service	EAP01CA92, CA53791, CA81063, ES08457

Keywords

Base excision repair
DNA
Reactive oxygen species

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/S0300-483X(03)00289-0

Cite this

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title = "Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage",

abstract = "The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.",

keywords = "Base excision repair, DNA, Reactive oxygen species",

author = "Tadahide Izumi and Wiederhold, {Lee R.} and Gargi Roy and Rabindra Roy and Arun Jaiswal and Bhakat, {Kishor K.} and Sankar Mitra and Hazra, {Tapas K.}",

note = "Funding Information: We would like to thank Dr. M. Park for his gift of FEN1 antibody, and Drs. D. Brown and M. Greenberg for their insights. We are grateful for Dr. D. Konkel for his editorial help, and Ms. W. Smith for her secretarial assistance. The work described in this review from the authors{\textquoteright} laboratories was supported by USPHS grants CA53791, CA81063, CA98664, ES08457, EAP01CA92, and Department of Energy grant (DE-FG-03-00ER63041). ",

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doi = "10.1016/S0300-483X(03)00289-0",

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T2 - Their interactions and role in repair of oxidative DNA damage

AU - Izumi, Tadahide

AU - Wiederhold, Lee R.

AU - Roy, Gargi

AU - Roy, Rabindra

AU - Jaiswal, Arun

AU - Bhakat, Kishor K.

AU - Mitra, Sankar

AU - Hazra, Tapas K.

N1 - Funding Information: We would like to thank Dr. M. Park for his gift of FEN1 antibody, and Drs. D. Brown and M. Greenberg for their insights. We are grateful for Dr. D. Konkel for his editorial help, and Ms. W. Smith for her secretarial assistance. The work described in this review from the authors’ laboratories was supported by USPHS grants CA53791, CA81063, CA98664, ES08457, EAP01CA92, and Department of Energy grant (DE-FG-03-00ER63041).

PY - 2003/11/15

Y1 - 2003/11/15

N2 - The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

AB - The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

KW - Base excision repair

KW - DNA

KW - Reactive oxygen species

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Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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