Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi, Lee R. Wiederhold, Gargi Roy, Rabindra Roy, Arun Jaiswal, Kishor K. Bhakat, Sankar Mitra, Tapas K. Hazra

Research output: Contribution to journalReview articlepeer-review

183 Scopus citations

Abstract

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

Original languageEnglish
Pages (from-to)43-65
Number of pages23
JournalToxicology
Volume193
Issue number1-2
DOIs
StatePublished - Nov 15 2003

Bibliographical note

Funding Information:
We would like to thank Dr. M. Park for his gift of FEN1 antibody, and Drs. D. Brown and M. Greenberg for their insights. We are grateful for Dr. D. Konkel for his editorial help, and Ms. W. Smith for her secretarial assistance. The work described in this review from the authors’ laboratories was supported by USPHS grants CA53791, CA81063, CA98664, ES08457, EAP01CA92, and Department of Energy grant (DE-FG-03-00ER63041).

Keywords

  • Base excision repair
  • DNA
  • Reactive oxygen species

ASJC Scopus subject areas

  • Toxicology

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