Management of antiplatelet therapy in patients undergoing neuroendovascular procedures

Keri S. Kim, Justin F. Fraser, Stephen Grupke, Aaron M. Cook

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Neuroendovascular techniques for treating cerebral aneurysms and other cerebrovascular pathology are increasingly becoming the standard of care. Intraluminal stents, aneurysm coils, and other flow diversion devices typically require concomitant antiplatelet therapy to reduce thromboembolic complications. The variability inherent with the pharmacodynamic response to common antiplatelet agents such as aspirin and clopidogrel complicates optimal selection of antiplatelet agents by clinicians. This review serves to discuss the literature related to antiplatelet use in neuroendovascular procedures and provides recommendations for clinicians on how to approach patients with variable response to antiplatelet agents, particularly clopidogrel.

Original languageEnglish
Pages (from-to)890-905
Number of pages16
JournalJournal of Neurosurgery
Volume129
Issue number4
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© AANS 2018.

Keywords

  • aneurysm
  • clopidogrel
  • intracranial stenosis
  • platelet reactivity
  • vascular disorders

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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