Abstract
Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means through which sensitization may be diagnosed, and highlight some of the new therapeutic options for managing the sensitized cardiac transplant patients.
Original language | English |
---|---|
Journal | OBM Transplantation |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jun 2021 |
Bibliographical note
Publisher Copyright:© 2020 by the author.
Keywords
- Cardiac transplant
- HLA antibodies
- Postoperative complications
- Sensitization
ASJC Scopus subject areas
- Biochemistry, medical
- Transplantation
- Surgery
- Immunology