Management of the Sensitized Cardiac Transplantation Recipient

Michael Mazzei, Suresh Keshavamurthy, Olga Timofeeva, Yoshiya Toyoda

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means through which sensitization may be diagnosed, and highlight some of the new therapeutic options for managing the sensitized cardiac transplant patients.

Original languageEnglish
JournalOBM Transplantation
Issue number1
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2020 by the author.


  • Cardiac transplant
  • HLA antibodies
  • Postoperative complications
  • Sensitization

ASJC Scopus subject areas

  • Biochemistry, medical
  • Transplantation
  • Surgery
  • Immunology


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