TY - JOUR
T1 - Manganese superoxide dismutase vs. p53
T2 - Regulation of mitochondrial ROS
AU - Holley, Aaron K.
AU - Dhar, Sanjit Kumar
AU - St. Clair, Daret K.
PY - 2010/11
Y1 - 2010/11
N2 - Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species (ROS) to carry out this interorganellar communication. The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and -independent mechanisms at both the nucleus and mitochondria. p53 affect mitochondrial ROS production, in part, by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production, and a breakdown of communication amongst mitochondria, p53, and the nucleus can have broad implications in disease development.
AB - Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species (ROS) to carry out this interorganellar communication. The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and -independent mechanisms at both the nucleus and mitochondria. p53 affect mitochondrial ROS production, in part, by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production, and a breakdown of communication amongst mitochondria, p53, and the nucleus can have broad implications in disease development.
KW - Manganese superoxide dismutase
KW - Mitochondria
KW - P53
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=78149361937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149361937&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2010.06.003
DO - 10.1016/j.mito.2010.06.003
M3 - Review article
C2 - 20601193
AN - SCOPUS:78149361937
SN - 1567-7249
VL - 10
SP - 649
EP - 661
JO - Mitochondrion
JF - Mitochondrion
IS - 6
ER -