Manganese superoxide dismutase vs. p53: Regulation of mitochondrial ROS

Aaron K. Holley, Sanjit Kumar Dhar, Daret K. St. Clair

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species (ROS) to carry out this interorganellar communication. The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and -independent mechanisms at both the nucleus and mitochondria. p53 affect mitochondrial ROS production, in part, by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production, and a breakdown of communication amongst mitochondria, p53, and the nucleus can have broad implications in disease development.

Original languageEnglish
Pages (from-to)649-661
Number of pages13
Issue number6
StatePublished - Nov 2010


  • Manganese superoxide dismutase
  • Mitochondria
  • P53
  • Reactive oxygen species

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology


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