TY - JOUR
T1 - Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete
AU - Hawas, Usama W.
AU - Shaaban, Mohamed
AU - Shaaban, Khaled A.
AU - Speitling, Michael
AU - Maier, Armin
AU - Kelter, Gerhard
AU - Fiebig, Heinz H.
AU - Meiners, Marinus
AU - Helmke, Elisabeth
AU - Laatsch, Hartmut
PY - 2009/12/28
Y1 - 2009/12/28
N2 - Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
AB - Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
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U2 - 10.1021/np900160g
DO - 10.1021/np900160g
M3 - Article
C2 - 19921834
AN - SCOPUS:74049083344
SN - 0163-3864
VL - 72
SP - 2120
EP - 2124
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 12
ER -