Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

Usama W. Hawas; Mohamed Shaaban; Khaled A. Shaaban; Michael Speitling; Armin Maier; Gerhard Kelter; Heinz H. Fiebig; Marinus Meiners; Elisabeth Helmke; Hartmut Laatsch

doi:10.1021/np900160g

Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

Usama W. Hawas, Mohamed Shaaban, Khaled A. Shaaban, Michael Speitling, Armin Maier, Gerhard Kelter, Heinz H. Fiebig, Marinus Meiners, Elisabeth Helmke, Hartmut Laatsch

Pharmaceutical Sciences

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89 Scopus citations

Abstract

Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

Original language	English
Pages (from-to)	2120-2124
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	12
DOIs	https://doi.org/10.1021/np900160g
State	Published - Dec 28 2009

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np900160g

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title = "Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete",

abstract = "Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.",

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T1 - Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

AU - Hawas, Usama W.

AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Speitling, Michael

AU - Maier, Armin

AU - Kelter, Gerhard

AU - Fiebig, Heinz H.

AU - Meiners, Marinus

AU - Helmke, Elisabeth

AU - Laatsch, Hartmut

PY - 2009/12/28

Y1 - 2009/12/28

N2 - Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

AB - Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

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Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

Abstract

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