Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

Usama W. Hawas, Mohamed Shaaban, Khaled A. Shaaban, Michael Speitling, Armin Maier, Gerhard Kelter, Heinz H. Fiebig, Marinus Meiners, Elisabeth Helmke, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)- 5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

Original languageEnglish
Pages (from-to)2120-2124
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number12
DOIs
StatePublished - Dec 28 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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