Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.
|State||Published - Dec 2021|
Bibliographical noteFunding Information:
Funding: The financial support of this work was funded by a grant from the Bundesministerium für Bildung und Forschung (BMBF, grant 03F0415A).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Marine-derived Streptomyces sp
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)