Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban, Khaled A. Shaaban, Gerhard Kelter, Heinz Herbert Fiebig, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

Original languageEnglish
Article number715
JournalMarine Drugs
Issue number12
StatePublished - Dec 2021

Bibliographical note

Funding Information:
Funding: The financial support of this work was funded by a grant from the Bundesministerium für Bildung und Forschung (BMBF, grant 03F0415A).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cytotoxicity
  • Isoquinolinequinones
  • Mansouramycins
  • Marine-derived Streptomyces sp

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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