Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban; Khaled A. Shaaban; Gerhard Kelter; Heinz Herbert Fiebig; Hartmut Laatsch

doi:10.3390/md19120715

Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban, Khaled A. Shaaban, Gerhard Kelter, Heinz Herbert Fiebig, Hartmut Laatsch

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

Original language	English
Article number	715
Journal	Marine Drugs
Volume	19
Issue number	12
DOIs	https://doi.org/10.3390/md19120715
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cytotoxicity
Isoquinolinequinones
Mansouramycins
Marine-derived Streptomyces sp

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md19120715

Cite this

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title = "Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes",

abstract = "Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.",

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doi = "10.3390/md19120715",

language = "English",

volume = "19",

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AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Kelter, Gerhard

AU - Fiebig, Heinz Herbert

AU - Laatsch, Hartmut

PY - 2021/12

Y1 - 2021/12

N2 - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

AB - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

KW - Cytotoxicity

KW - Isoquinolinequinones

KW - Mansouramycins

KW - Marine-derived Streptomyces sp

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DO - 10.3390/md19120715

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JO - Marine Drugs

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Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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