Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban; Khaled A. Shaaban; Gerhard Kelter; Heinz Herbert Fiebig; Hartmut Laatsch

doi:10.3390/md19120715

Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban
, Khaled A. Shaaban
, Gerhard Kelter
, Heinz Herbert Fiebig
, Hartmut Laatsch

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

Original language	English
Article number	715
Journal	Marine Drugs
Volume	19
Issue number	12
DOIs	https://doi.org/10.3390/md19120715
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Funding: The financial support of this work was funded by a grant from the Bundesministerium für Bildung und Forschung (BMBF, grant 03F0415A).

Funders	Funder number
Bundesministerium für Bildung und Forschung	03F0415A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

Cytotoxicity
Isoquinolinequinones
Mansouramycins
Marine-derived Streptomyces sp

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Access to Document

10.3390/md19120715

Cite this

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title = "Mansouramycins E{\textendash}G, cytotoxic isoquinolinequinones from marine streptomycetes",

abstract = "Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E{\textendash}G (1a{\textendash}3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.",

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author = "Mohamed Shaaban and Shaaban, \{Khaled A.\} and Gerhard Kelter and Fiebig, \{Heinz Herbert\} and Hartmut Laatsch",

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month = dec,

doi = "10.3390/md19120715",

language = "English",

volume = "19",

number = "12",

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T1 - Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Kelter, Gerhard

AU - Fiebig, Heinz Herbert

AU - Laatsch, Hartmut

PY - 2021/12

Y1 - 2021/12

N2 - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

AB - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

KW - Cytotoxicity

KW - Isoquinolinequinones

KW - Mansouramycins

KW - Marine-derived Streptomyces sp

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UR - https://www.scopus.com/pages/publications/85121605835#tab=citedBy

U2 - 10.3390/md19120715

DO - 10.3390/md19120715

M3 - Article

C2 - 34940714

AN - SCOPUS:85121605835

SN - 1660-3397

VL - 19

JO - Marine Drugs

JF - Marine Drugs

IS - 12

M1 - 715

ER -

Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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