Mapping drug-induced changes in cerebral R2* by multiple gradient recalled echo functional MRI

Q. Chen; A. H. Andersen; Z. Zhang; A. Ovadia; D. M. Gash; Malcolm J. Avison

doi:10.1016/0730-725X(95)02100-8

Mapping drug-induced changes in cerebral R₂* by multiple gradient recalled echo functional MRI

Q. Chen, A. H. Andersen, Z. Zhang, A. Ovadia, D. M. Gash, Malcolm J. Avison

Neuroscience

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R₂*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6- tetrahydropyridine hydrochloride (MPTP). R₂* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R₂* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R₂* change support the view that the method is monitoring changes in neural activity.

Original language	English
Pages (from-to)	469-476
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(95)02100-8
State	Published - 1996

Bibliographical note

Funding Information:
Acknowledgements-We are grateful to Dr. Charles Smith for helpful discussions in the course: of this work. This work was supported by NIH Grant NS-25778 to D.M. Gash, and the Vice Chancellor for Research & Graduate Studiles, UK Medical Center to M.J. Avison.

Keywords

BOLD
Basal ganglia
Brain mapping
Dopamine
Levodopa
MRI
Parkinson's disease
Rhesus
Striatum

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/0730-725X(95)02100-8

Cite this

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title = "Mapping drug-induced changes in cerebral R2* by multiple gradient recalled echo functional MRI",

abstract = "A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6- tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.",

keywords = "BOLD, Basal ganglia, Brain mapping, Dopamine, Levodopa, MRI, Parkinson's disease, Rhesus, Striatum",

author = "Q. Chen and Andersen, {A. H.} and Z. Zhang and A. Ovadia and Gash, {D. M.} and Avison, {Malcolm J.}",

note = "Funding Information: Acknowledgements-We are grateful to Dr. Charles Smith for helpful discussions in the course: of this work. This work was supported by NIH Grant NS-25778 to D.M. Gash, and the Vice Chancellor for Research & Graduate Studiles, UK Medical Center to M.J. Avison.",

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AU - Andersen, A. H.

AU - Zhang, Z.

AU - Ovadia, A.

AU - Gash, D. M.

AU - Avison, Malcolm J.

N1 - Funding Information: Acknowledgements-We are grateful to Dr. Charles Smith for helpful discussions in the course: of this work. This work was supported by NIH Grant NS-25778 to D.M. Gash, and the Vice Chancellor for Research & Graduate Studiles, UK Medical Center to M.J. Avison.

PY - 1996

Y1 - 1996

N2 - A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6- tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.

AB - A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6- tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.

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KW - Basal ganglia

KW - Brain mapping

KW - Dopamine

KW - Levodopa

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KW - Parkinson's disease

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KW - Striatum

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