Mapping drug-induced changes in cerebral R2* by multiple gradient recalled echo functional MRI

Q. Chen, A. H. Andersen, Z. Zhang, A. Ovadia, D. M. Gash, Malcolm J. Avison

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6- tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalMagnetic Resonance Imaging
Issue number5
StatePublished - 1996

Bibliographical note

Funding Information:
Acknowledgements-We are grateful to Dr. Charles Smith for helpful discussions in the course: of this work. This work was supported by NIH Grant NS-25778 to D.M. Gash, and the Vice Chancellor for Research & Graduate Studiles, UK Medical Center to M.J. Avison.


  • BOLD
  • Basal ganglia
  • Brain mapping
  • Dopamine
  • Levodopa
  • MRI
  • Parkinson's disease
  • Rhesus
  • Striatum

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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