TY - JOUR
T1 - Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer’s disease
AU - Aschenbrenner, Andrew J.
AU - Asaad Baksh, R.
AU - Benejam, Bessy
AU - Beresford-Webb, Jessica A.
AU - Coppus, Antonia
AU - Fortea, Juan
AU - Handen, Benjamin L.
AU - Hartley, Sigan
AU - Head, Elizabeth
AU - Jaeger, Judith
AU - Levin, Johannes
AU - Loosli, Sandra V.
AU - Rebillat, Anne Sophie
AU - Sacco, Silvia
AU - Schmitt, Frederick A.
AU - Thurlow, Kate E.
AU - Zaman, Shahid
AU - Hassenstab, Jason
AU - Strydom, Andre
N1 - Publisher Copyright:
© 2021 The Authors.
PY - 2021
Y1 - 2021
N2 - Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer’s disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time.We then conducted additional analyses to provide support for the utility of the composites. The composites were presented to an expert panel to determine the most optimal cognitive battery based on predetermined criteria. Results: There were common cognitive domains across site composites, which were sensitive to early decline. The final composite consisted ofmemory, language/executive functioning, selective attention, orientation, and praxis tests. Discussion:We have identified a composite that is sensitive to early decline and thus may have utility as an outcome measure in trials to prevent or delay symptoms of AD in DS.
AB - Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer’s disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time.We then conducted additional analyses to provide support for the utility of the composites. The composites were presented to an expert panel to determine the most optimal cognitive battery based on predetermined criteria. Results: There were common cognitive domains across site composites, which were sensitive to early decline. The final composite consisted ofmemory, language/executive functioning, selective attention, orientation, and praxis tests. Discussion:We have identified a composite that is sensitive to early decline and thus may have utility as an outcome measure in trials to prevent or delay symptoms of AD in DS.
KW - Alzheimer’s disease
KW - Clinical trial outcome
KW - Composite measure
KW - Down syndrome
KW - Early cognitive decline
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U2 - 10.1002/dad2.12184
DO - 10.1002/dad2.12184
M3 - Article
AN - SCOPUS:85108417270
VL - 13
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12184
ER -