TY - JOUR
T1 - Maternal periodontitis treatment and child neurodevelopment at 24 to 28 months of age
AU - Michalowicz, Bryan S.
AU - Hodges, James S.
AU - Lussky, Richard C.
AU - Bada, Henrietta
AU - Rawson, Twila
AU - Buttross, L. Susan
AU - Chiriboga, Claudia
AU - DiAngelis, Anthony J.
AU - Novak, M. John
AU - Buchanan, William
AU - Mitchell, Dennis A.
AU - Papapanou, Panos N.
PY - 2011/5
Y1 - 2011/5
N2 - BACKGROUND: Some maternal infections are associated with impaired infant cognitive and motor performance. Periodontitis results in frequent bacteremia and elevated serum inflammatory mediators. OBJECTIVE: The purpose of this study was to determine if periodontitis treatment in pregnant women affects infant cognitive, motor, or language development. METHODS: Children born to women who had participated in a previous trial were assessed between 24 and 28 months of age by using the Bayley Scales of Infant and Toddler Development (Third Edition) and the Preschool Language Scale (Fourth Edition). Information about the pregnancy, neonatal period, and home environment was obtained through chart abstractions, laboratory test results, and questionnaires. We compared infants born to women treated for periodontitis before 21 weeks' gestation (treatment group) or after delivery (controls). In unadjusted and adjusted analyses, associations between change in maternal periodontal condition during pregnancy and neurodevelopment scores were tested by using Student's t tests and linear regression. RESULTS: A total of 411 of 791 eligible mother/caregiver-child pairs participated. Thirty-seven participating children (9.0%) were born at <37 weeks' gestation. Infants in the treatment and control groups did not differ significantly for adjusted mean cognitive (90.7 vs 91.4), motor (96.8 vs 97.2), or language (92.2 vs 92.1) scores (all P>.5). Results were similar in adjusted analyses. Children of women who experienced greater improvements in periodontal health had significantly higher motor and cognitive scores (P=.01 and .02, respectively), although the effect was small (∼1-point increase for each SD increase in the periodontal measure). CONCLUSION: Nonsurgical periodontitis treatment in pregnant women was not associated with cognitive, motor, or language development in these study children.
AB - BACKGROUND: Some maternal infections are associated with impaired infant cognitive and motor performance. Periodontitis results in frequent bacteremia and elevated serum inflammatory mediators. OBJECTIVE: The purpose of this study was to determine if periodontitis treatment in pregnant women affects infant cognitive, motor, or language development. METHODS: Children born to women who had participated in a previous trial were assessed between 24 and 28 months of age by using the Bayley Scales of Infant and Toddler Development (Third Edition) and the Preschool Language Scale (Fourth Edition). Information about the pregnancy, neonatal period, and home environment was obtained through chart abstractions, laboratory test results, and questionnaires. We compared infants born to women treated for periodontitis before 21 weeks' gestation (treatment group) or after delivery (controls). In unadjusted and adjusted analyses, associations between change in maternal periodontal condition during pregnancy and neurodevelopment scores were tested by using Student's t tests and linear regression. RESULTS: A total of 411 of 791 eligible mother/caregiver-child pairs participated. Thirty-seven participating children (9.0%) were born at <37 weeks' gestation. Infants in the treatment and control groups did not differ significantly for adjusted mean cognitive (90.7 vs 91.4), motor (96.8 vs 97.2), or language (92.2 vs 92.1) scores (all P>.5). Results were similar in adjusted analyses. Children of women who experienced greater improvements in periodontal health had significantly higher motor and cognitive scores (P=.01 and .02, respectively), although the effect was small (∼1-point increase for each SD increase in the periodontal measure). CONCLUSION: Nonsurgical periodontitis treatment in pregnant women was not associated with cognitive, motor, or language development in these study children.
KW - Child neurodevelopment
KW - Periodontitis
KW - Pregnancy
KW - Treatment
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U2 - 10.1542/peds.2010-3129
DO - 10.1542/peds.2010-3129
M3 - Article
C2 - 21482606
AN - SCOPUS:79955495410
SN - 0031-4005
VL - 127
SP - e1212-e1220
JO - Pediatrics
JF - Pediatrics
IS - 5
ER -