Maternal tobacco smoking, nicotine replacement and neurobehavioural development

James R. Pauly, Theodore A. Slotkin

Research output: Contribution to journalReview articlepeer-review

183 Scopus citations


The adverse effects of prenatal cigarette smoke exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, approximately 25% of women of childbearing age currently smoke cigarettes, and only a small percentage of these individuals quit after learning of their pregnancy. Women interested in smoking cessation during pregnancy have a number of options, including behavioural and pharmacological aids, but nicotine replacement therapy (NRT) is by far the most common approach. While NRT avoids exposure to the myriad compounds present in tobacco smoke, nicotine itself causes damage to the developing nervous system. The purpose of this article is to review the detrimental effects of developmental tobacco smoke exposure on short- and long-term outcomes with particular emphasis on neurobehavioural consequences. In conclusion based on the clear, adverse effects of nicotine on brain development observed in human and animal studies, we suggest that safer alternatives for smoking cessation in pregnancy are badly needed.

Original languageEnglish
Pages (from-to)1331-1337
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Issue number10
StatePublished - Oct 2008


  • ADHD
  • Cytisine
  • Nicotine replacement therapy
  • Nicotinic receptor
  • Sudden infant death syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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