Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

Ashlee N. Ford Versypt; Daniel W. Pack; Richard D. Braatz

doi:10.1016/j.jconrel.2012.10.015

Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

Ashlee N. Ford Versypt, Daniel W. Pack, Richard D. Braatz

Research output: Contribution to journal › Review article › peer-review

284 Scopus citations

Abstract

PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Journal of Controlled Release
Volume	165
Issue number	1
DOIs	https://doi.org/10.1016/j.jconrel.2012.10.015
State	Published - Jan 10 2013

Bibliographical note

Funding Information:
This work was made possible through the support of the National Institutes of Health ( NIBIB 5RO1EB005181 ) and the National Science Foundation (grant # 0426328 ). A.N. Ford Versypt acknowledges the support of the U.S. Department of Energy Computational Science Graduate Fellowship Program of the Office of Science and National Nuclear Security Administration in the Department of Energy under contract DE-FG02-97ER25308 .

Keywords

Autocatalysis
Bulk degradation
Controlled release drug delivery
Degradable polymer
Modeling
PLGA

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.jconrel.2012.10.015

Cite this

@article{556c56a6e340415fa7cdcee3f0154480,

title = "Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review",

abstract = "PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.",

keywords = "Autocatalysis, Bulk degradation, Controlled release drug delivery, Degradable polymer, Modeling, PLGA",

author = "{Ford Versypt}, {Ashlee N.} and Pack, {Daniel W.} and Braatz, {Richard D.}",

note = "Funding Information: This work was made possible through the support of the National Institutes of Health ( NIBIB 5RO1EB005181 ) and the National Science Foundation (grant # 0426328 ). A.N. Ford Versypt acknowledges the support of the U.S. Department of Energy Computational Science Graduate Fellowship Program of the Office of Science and National Nuclear Security Administration in the Department of Energy under contract DE-FG02-97ER25308 .",

year = "2013",

month = jan,

day = "10",

doi = "10.1016/j.jconrel.2012.10.015",

language = "English",

volume = "165",

pages = "29--37",

number = "1",

}

TY - JOUR

T1 - Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

AU - Ford Versypt, Ashlee N.

AU - Pack, Daniel W.

AU - Braatz, Richard D.

N1 - Funding Information: This work was made possible through the support of the National Institutes of Health ( NIBIB 5RO1EB005181 ) and the National Science Foundation (grant # 0426328 ). A.N. Ford Versypt acknowledges the support of the U.S. Department of Energy Computational Science Graduate Fellowship Program of the Office of Science and National Nuclear Security Administration in the Department of Energy under contract DE-FG02-97ER25308 .

PY - 2013/1/10

Y1 - 2013/1/10

N2 - PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.

AB - PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.

KW - Autocatalysis

KW - Bulk degradation

KW - Controlled release drug delivery

KW - Degradable polymer

KW - Modeling

KW - PLGA

UR - http://www.scopus.com/inward/record.url?scp=84869879002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869879002&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2012.10.015

DO - 10.1016/j.jconrel.2012.10.015

M3 - Review article

C2 - 23103455

AN - SCOPUS:84869879002

SN - 0168-3659

VL - 165

SP - 29

EP - 37

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1

ER -

Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this