Measurement of oxygen radicals and lipid peroxidation in neural tissues.

E. D. Hall, P. K. Andrus

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


An important role for oxygen radical-mediated neuronal damage has been implicated in a number of acute and chronic neurodegenerative disorders. Particular interest has centered upon oxygen radical-induced, iron-catalyzed lipid peroxidation (LP) as the principal mechanism of the neuronal injury associated with oxygen radicals. Thus, there has been a growing interest in methods for monitoring increased oxygen radical levels as an index of oxidative stress as well as markers of LP-associated oxidative injury in a number of in vitro and in vivo model systems. This unit provides a detailed description of the salicylate trapping method for the measurement of the most highly reactive oxygen radical, the hydroxyl radical, as well as several direct or indirect methods for assessment of cellular LP in either cell cultures or in in vivo models.

Original languageEnglish
Pages (from-to)Unit7.17
JournalCurrent Protocols in Neuroscience
VolumeChapter 7
StatePublished - May 2001

ASJC Scopus subject areas

  • General Neuroscience


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