Measuring natural selection on genotypes and phenotypes in the wild

C. R. Linnen, H. E. Hoekstra

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

41 Scopus citations

Abstract

A complete understanding of the role of natural selection in driving evolutionary change requires accurate estimates of the strength of selection acting in the wild. Accordingly, several approaches using a variety of data - including patterns of DNA variability, spatial and temporal changes in allele frequencies, and fitness estimates - have been developed to identify and quantify selection on both genotypes and phenotypes. Here, we review these approaches, drawing on both recent and classic examples to illustrate their utility and limitations. We then argue that by combining estimates of selection at multiple levels - from individual mutations to phenotypes-and at multiple timescales - from ecological to evolutionary - with experiments that demonstrate why traits are under selection, we can gain a much more complete picture of the adaptive process.

Original languageEnglish
Title of host publicationCold Spring Harbor Symposia on Quantitative Biology
Pages155-168
Number of pages14
DOIs
StatePublished - 2009

Publication series

NameCold Spring Harbor Symposia on Quantitative Biology
Volume74
ISSN (Print)0091-7451

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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