Abstract
Mechanical ventilation is a potentially life-saving therapy for patients with acute lung injury, but the ventilator itself may cause lung injury. Ventilator-induced lung injury (VILI) is sometimes an unfortunate consequence of mechanical ventilation. It is not clear however how best to minimize VILI through adjustment of various parameters including tidal volume, plateau pressure, driving pressure, and positive end expiratory pressure (PEEP). No single parameter provides a clear indication for onset of lung injury attributable exclusively to the ventilator. There is currently interest in quantifying how static and dynamic parameters contribute to VILI. One concept that has emerged is the consideration of the amount of energy transferred from the ventilator to the respiratory system per unit time, which can be quantified as mechanical power. This review article reports on recent literature in this emerging field and future roles for mechanical power assessments in prospective studies.
Original language | English |
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Pages (from-to) | 537-545 |
Number of pages | 9 |
Journal | American Journal of the Medical Sciences |
Volume | 362 |
Issue number | 6 |
DOIs | |
State | Accepted/In press - 2021 |
Bibliographical note
Funding Information:This work was supported in part by National Heart, Lung, and Blood Institute Grants HL131526 and HL151419 (CMW).
Publisher Copyright:
© 2021 Southern Society for Clinical Investigation
Keywords
- Acute respiratory distress syndromes
- Mechanical energy
- Mechanical power
- Mechanical ventilator
- Ventilator induced lung injury
ASJC Scopus subject areas
- General Medicine