Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse

D. W. Horohov, T. L. Keadle, S. S. Pourciau, M. A. Littlefield-Chabaud, S. G. Kamerling, M. L. Keowen, D. D. French, P. A. Melrose

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression, LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.

Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalVeterinary Immunology and Immunopathology
Issue number3-4
StatePublished - Oct 1996

Bibliographical note

Funding Information:
The generous support from the Grayson Jockey Club, Inc. and the Equine Veterinary Research Program of the LSU School of Veterinary Medicine are gratefully acknowledged. TLK was supported through a LSU Board of Reagents Scholarship.


  • Horse
  • IL-2
  • Immune system
  • LAK

ASJC Scopus subject areas

  • Immunology
  • General Veterinary


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