Mechanism of Prostaglandin E2 Stimulation of Renin Secretion

J. L. Osborn, B. Noordewier, J. B. Hook, M. D. Bailie

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Nov 1978

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Mechanism of Prostaglandin E2 Stimulation of Renin Secretion'. Together they form a unique fingerprint.

Cite this