Mechanism of Prostaglandin E2 Stimulation of Renin Secretion

J. L. Osborn; B. Noordewier; J. B. Hook; M. D. Bailie

doi:10.3181/00379727-159-40325

Mechanism of Prostaglandin E₂ Stimulation of Renin Secretion

J. L. Osborn, B. Noordewier, J. B. Hook, M. D. Bailie

Biology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE₂ increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE₂ but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE₂ increases renin secretion by a direct effect on the juxtaglomerular apparatus.

Original language	English
Pages (from-to)	249-252
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	159
Issue number	2
DOIs	https://doi.org/10.3181/00379727-159-40325
State	Published - Nov 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)

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abstract = "Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.",

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N2 - Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.

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Mechanism of Prostaglandin E₂ Stimulation of Renin Secretion

Abstract

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