TY - JOUR
T1 - Mechanism of Prostaglandin E2 Stimulation of Renin Secretion
AU - Osborn, J. L.
AU - Noordewier, B.
AU - Hook, J. B.
AU - Bailie, M. D.
PY - 1978/11
Y1 - 1978/11
N2 - Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.
AB - Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.
UR - http://www.scopus.com/inward/record.url?scp=0018245659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018245659&partnerID=8YFLogxK
U2 - 10.3181/00379727-159-40325
DO - 10.3181/00379727-159-40325
M3 - Article
C2 - 714953
AN - SCOPUS:0018245659
SN - 0037-9727
VL - 159
SP - 249
EP - 252
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -