TY - JOUR
T1 - Mechanism of serf-tolerance of γ/δ t cells in epithelial tissue
AU - Barrett, Terrence A.
AU - Delvy, Michelle L.
AU - Kennedy, David M.
AU - Lefrancois, Leo
AU - Matis, Louis A.
AU - Dent, Alexander L.
AU - Hedrick, Stephen M.
AU - Bluestone, Jeffrey A.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The present study examined mechanisms of tolerance for T cell receptor γ/δ (TCR-γ/δ) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR- γ/δ cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Agbearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-γ/δ cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.
AB - The present study examined mechanisms of tolerance for T cell receptor γ/δ (TCR-γ/δ) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR- γ/δ cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Agbearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-γ/δ cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.
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U2 - 10.1084/jem.175.1.65
DO - 10.1084/jem.175.1.65
M3 - Article
C2 - 1730927
AN - SCOPUS:0026557387
VL - 175
SP - 65
EP - 70
IS - 1
ER -