Mechanism of serf-tolerance of γ/δ t cells in epithelial tissue

Terrence A. Barrett, Michelle L. Delvy, David M. Kennedy, Leo Lefrancois, Louis A. Matis, Alexander L. Dent, Stephen M. Hedrick, Jeffrey A. Bluestone

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The present study examined mechanisms of tolerance for T cell receptor γ/δ (TCR-γ/δ) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR- γ/δ cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Agbearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-γ/δ cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalJournal of Experimental Medicine
Issue number1
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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