TY - JOUR
T1 - Mechanisms of neuronal death in brain aging and alzheimer's disease
T2 - Role of endocrine‐mediated calcium dyshomeostasis
AU - Landfield, Philip W.
AU - Thibault, Olivier
AU - Mazzanti, Mary L.
AU - Porter, Nada M.
AU - Kerr, D. Steven
PY - 1992/11
Y1 - 1992/11
N2 - This paper reviews evidence that brain aging and Alzheimer's disease (AD) are somehow closely related and that the hippocampus (CA1) is highly vulnerable to cell loss under both conditions. In addition, two current lines of evidence on the mechanisms of hippocampal cell loss with aging are considered, including studies of neuronal calcium dysregulation and studies of cumulative glucocorticoid (GC) neurotoxicity. Moreover, recent electro‐physiological studies have shown that excess glucocorticoid activation of hippocampal neurons increases the influx of calcium through voltage‐activated calcium channels. Second messenger systems may mediate the steroid modulation of calcium channels. Therefore, it is hypothesized that excess glucocorticoid activation and neuronal calcium dysregulation may be two phases of a single process that increases the susceptibility of neurons to neurodegeneration during aging and Alzheimer's disease. © 1992 John Wiley & Sons, Inc.
AB - This paper reviews evidence that brain aging and Alzheimer's disease (AD) are somehow closely related and that the hippocampus (CA1) is highly vulnerable to cell loss under both conditions. In addition, two current lines of evidence on the mechanisms of hippocampal cell loss with aging are considered, including studies of neuronal calcium dysregulation and studies of cumulative glucocorticoid (GC) neurotoxicity. Moreover, recent electro‐physiological studies have shown that excess glucocorticoid activation of hippocampal neurons increases the influx of calcium through voltage‐activated calcium channels. Second messenger systems may mediate the steroid modulation of calcium channels. Therefore, it is hypothesized that excess glucocorticoid activation and neuronal calcium dysregulation may be two phases of a single process that increases the susceptibility of neurons to neurodegeneration during aging and Alzheimer's disease. © 1992 John Wiley & Sons, Inc.
KW - Alzheimer's Disease
KW - brain aging
KW - calcium currents
KW - calcium potentials
KW - calcium regulation
KW - glucocorticoids
KW - hippocampus
KW - neuron death
UR - http://www.scopus.com/inward/record.url?scp=0026495712&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026495712&partnerID=8YFLogxK
U2 - 10.1002/neu.480230914
DO - 10.1002/neu.480230914
M3 - Article
C2 - 1469387
AN - SCOPUS:0026495712
SN - 0022-3034
VL - 23
SP - 1247
EP - 1260
JO - Journal of Neurobiology
JF - Journal of Neurobiology
IS - 9
ER -