Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Michal Toborek; Yong Woo Lee; Govinder Flora; Hong Pu; Ibolya E. András; Edward Wylegala; Bernhard Hennig; Avindra Nath

doi:10.1007/s10571-004-1383-x

Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Michal Toborek, Yong Woo Lee, Govinder Flora, Hong Pu, Ibolya E. András, Edward Wylegala, Bernhard Hennig, Avindra Nath

Research output: Contribution to journal › Review article › peer-review

191 Scopus citations

Abstract

1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

Original language	English
Pages (from-to)	181-199
Number of pages	19
Journal	Cellular and Molecular Neurobiology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/s10571-004-1383-x
State	Published - Feb 2005

Bibliographical note

Funding Information:
This work was supported by NIH (NS39254, MH63022, and AA013843).

Keywords

AIDS
Blood-brain barrier
Brain endothelial cells
HIV
Inflammatory responses
Tat
Tight junction

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10571-004-1383-x

Cite this

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title = "Mechanisms of the blood-brain barrier disruption in HIV-1 infection",

abstract = "1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.",

keywords = "AIDS, Blood-brain barrier, Brain endothelial cells, HIV, Inflammatory responses, Tat, Tight junction",

author = "Michal Toborek and Lee, {Yong Woo} and Govinder Flora and Hong Pu and Andr{\'a}s, {Ibolya E.} and Edward Wylegala and Bernhard Hennig and Avindra Nath",

note = "Funding Information: This work was supported by NIH (NS39254, MH63022, and AA013843).",

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doi = "10.1007/s10571-004-1383-x",

language = "English",

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AU - Toborek, Michal

AU - Lee, Yong Woo

AU - Flora, Govinder

AU - Pu, Hong

AU - András, Ibolya E.

AU - Wylegala, Edward

AU - Hennig, Bernhard

AU - Nath, Avindra

N1 - Funding Information: This work was supported by NIH (NS39254, MH63022, and AA013843).

PY - 2005/2

Y1 - 2005/2

N2 - 1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

AB - 1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

KW - AIDS

KW - Blood-brain barrier

KW - Brain endothelial cells

KW - HIV

KW - Inflammatory responses

KW - Tat

KW - Tight junction

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DO - 10.1007/s10571-004-1383-x

M3 - Review article

C2 - 15962513

AN - SCOPUS:17644380598

SN - 0272-4340

VL - 25

SP - 181

EP - 199

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

IS - 1

ER -

Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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