TY - JOUR
T1 - Mechanisms of use-dependent plasticity in the human motor cortex
AU - Bütefisch, Cathrin M.
AU - Davis, Benjamin C.
AU - Wise, Steven P.
AU - Sawaki, Lumy
AU - Kopylev, Leonid
AU - Classen, Joseph
AU - Cohen, Leonardo G.
PY - 2000/3/28
Y1 - 2000/3/28
N2 - Practicing movements results in improvement in performance and in plasticity of the motor cortex. To identify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated with drugs that influence synaptic plasticity. Use-dependent plasticity was reduced substantially by dextromethorphan (an N-methyl-D-aspartate receptor blocker) and by lorazepam [a γ-aminobutyric acid (GABA) type A receptor-positive allosteric modulator]. These results identify N-methyl-D-aspartate receptor activation and GABAergic inhibition as mechanisms operating in use-dependent plasticity in intact human motor cortex and point to similarities in the mechanisms underlying this form of plasticity and long-term potentiation.
AB - Practicing movements results in improvement in performance and in plasticity of the motor cortex. To identify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated with drugs that influence synaptic plasticity. Use-dependent plasticity was reduced substantially by dextromethorphan (an N-methyl-D-aspartate receptor blocker) and by lorazepam [a γ-aminobutyric acid (GABA) type A receptor-positive allosteric modulator]. These results identify N-methyl-D-aspartate receptor activation and GABAergic inhibition as mechanisms operating in use-dependent plasticity in intact human motor cortex and point to similarities in the mechanisms underlying this form of plasticity and long-term potentiation.
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U2 - 10.1073/pnas.97.7.3661
DO - 10.1073/pnas.97.7.3661
M3 - Article
C2 - 10716702
AN - SCOPUS:0034724403
SN - 0027-8424
VL - 97
SP - 3661
EP - 3665
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -