Mechanochemical Sensing: A Biomimetic Sensing Strategy

Prakash Shrestha, Shankar Mandal, Hanbin Mao

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Existing biosensors employ two major components: analyte recognition and signal transduction. Although specificity is achieved through analyte recognition, sensitivity is usually enhanced through a chemical amplification stage that couples the two main units in a sensor. Although highly sensitive, the extra chemical amplification stage complicates the sensing protocol. In addition, it separates the two elements spatiotemporally, reducing the real-time response of the biosensor. In this review, we discuss the new mechanochemical biosensors that employ mechanochemical coupling strategies to overcome these issues. By monitoring changes in the mechanical properties of a single-molecule template upon analyte binding, single-molecule sensitivity is reached. As chemical amplification becomes unnecessary in this single-molecule mechanochemical sensing (SMMS) strategy, real-time sensing is achieved. One spanner short New mechanochemical biosensors that employ mechanochemical coupling strategies to overcome the issues of existing biosensors are reviewed. By monitoring changes in the mechanical properties of a single-molecule template upon analyte binding, single-molecule sensitivity can be reached.

Original languageEnglish
Pages (from-to)1829-1837
Number of pages9
JournalChemPhysChem
Volume16
Issue number9
DOIs
StatePublished - Jun 1 2015

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • biosensors
  • DNA
  • mechanochemical sensing
  • optical tweezers
  • single-molecule techniques

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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