Medications Approved for Preventing Migraine Headaches

Brittany L. Spindler, Melody Ryan

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Migraine is the third-most prevalent disease in the world and affects approximately 39 million individuals in the United States alone. Migraine occurs in nearly 1 in 7 individuals between 15 and 49 years of age and is 3 times more frequent in women than in men. The Food and Drug Administration (FDA) recently approved 3 new humanized monoclonal antibodies that target calcitonin gene-related peptide (CGRP): erenumab, fremanezumab, and galcanezumab. The agents either bind to the CGRP receptor (erenumab) or bind to the CGRP ligand (fremanezumab and galcanezumab) and block its binding to the receptor. All 3 products are indicated for preventative treatment of episodic or chronic migraine in adults. The available studies to date document that these agents reduce migraine attacks. The CGRP monoclonal antibodies offer patients new options once they have exhausted other treatments.

Original languageEnglish
Pages (from-to)664-667
Number of pages4
JournalAmerican Journal of Medicine
Issue number6
StatePublished - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.


  • Calcitonin gene-related peptide (CGRP)
  • Headache
  • Migraine

ASJC Scopus subject areas

  • General Medicine


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