TY - JOUR
T1 - Megalin
T2 - A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis
AU - Kukida, Masayoshi
AU - Sawada, Hisashi
AU - Daugherty, Alan
AU - Lu, Hong S.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.
AB - Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.
KW - Atherosclerosis
KW - Kidney
KW - Megalin
KW - Renin angiotensin system
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U2 - 10.1016/j.phrs.2019.104537
DO - 10.1016/j.phrs.2019.104537
M3 - Review article
C2 - 31707037
AN - SCOPUS:85075197808
SN - 1043-6618
VL - 151
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 104537
ER -