Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis

Masayoshi Kukida, Hisashi Sawada, Alan Daugherty, Hong S. Lu

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.

Original languageEnglish
Article number104537
JournalPharmacological Research
Volume151
DOIs
StatePublished - Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Funding

The authors’ research work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award numbers R01HL133723 and R01HL139748 and the American Heart Association SFRN in Vascular Disease ( 18SFRN33960001 ). Hisashi Sawada is supported by an American Heart Association postdoctoral fellowship ( 18POST33990468 ). Megalin-related research work is supported by R01HL139748 . The content in this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

FundersFunder number
National Institutes of Health (NIH)R01HL133723
National Heart, Lung, and Blood Institute (NHLBI)R01HL139748
American Heart Association18POST33990468, 18SFRN33960001

    Keywords

    • Atherosclerosis
    • Kidney
    • Megalin
    • Renin angiotensin system

    ASJC Scopus subject areas

    • Pharmacology

    Fingerprint

    Dive into the research topics of 'Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis'. Together they form a unique fingerprint.

    Cite this