Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei

Vincent M. Cassone; Michael H. Roberts; Robert Y. Moore

doi:10.1016/0304-3940(87)90335-1

Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei

Vincent M. Cassone, Michael H. Roberts, Robert Y. Moore

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Abstract

The pineal hormone melatonin has been implicated in the regulation of circadian rhythms and in photoperiodic control of reproduction. The effects of melatonin require the hypothalamic suprachiasmatic nucleus (SCN), a principal pacemaker controlling circadian rhythms. To determine whether SCN activity was directly affected by exogenous melatonin, rats received either melatonin or saline injections 15 min before administration of 2-deoxy-[1-¹⁴C]glucose (2-DG) at two times of day, circadian time (CT) 10 and CT14, and the brains of these rats were processed for autoradiographic determination of 2-DG uptake within the SCN. We report that SCN 2-DG uptake was inhibited by melatonin at CT10, when 2-DG uptake is normally high, and unaffected at CT14, when 2-DG uptake is normally low. This indicates that the SCN may be neural substrates through which melatonin exerts at least some of its effects on mammalian physiology.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Neuroscience Letters
Volume	81
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(87)90335-1
State	Published - Oct 16 1987

Bibliographical note

Funding Information:
This researchw as supportedb y NSF Grant NS-16304t o R.Y.M.

Keywords

Circadian rhythm
Melatonin
Pineal gland
Suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/0304-3940(87)90335-1

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title = "Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei",

abstract = "The pineal hormone melatonin has been implicated in the regulation of circadian rhythms and in photoperiodic control of reproduction. The effects of melatonin require the hypothalamic suprachiasmatic nucleus (SCN), a principal pacemaker controlling circadian rhythms. To determine whether SCN activity was directly affected by exogenous melatonin, rats received either melatonin or saline injections 15 min before administration of 2-deoxy-[1-14C]glucose (2-DG) at two times of day, circadian time (CT) 10 and CT14, and the brains of these rats were processed for autoradiographic determination of 2-DG uptake within the SCN. We report that SCN 2-DG uptake was inhibited by melatonin at CT10, when 2-DG uptake is normally high, and unaffected at CT14, when 2-DG uptake is normally low. This indicates that the SCN may be neural substrates through which melatonin exerts at least some of its effects on mammalian physiology.",

keywords = "Circadian rhythm, Melatonin, Pineal gland, Suprachiasmatic nucleus",

author = "Cassone, {Vincent M.} and Roberts, {Michael H.} and Moore, {Robert Y.}",

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AU - Cassone, Vincent M.

AU - Roberts, Michael H.

AU - Moore, Robert Y.

N1 - Funding Information: This researchw as supportedb y NSF Grant NS-16304t o R.Y.M.

PY - 1987/10/16

Y1 - 1987/10/16

N2 - The pineal hormone melatonin has been implicated in the regulation of circadian rhythms and in photoperiodic control of reproduction. The effects of melatonin require the hypothalamic suprachiasmatic nucleus (SCN), a principal pacemaker controlling circadian rhythms. To determine whether SCN activity was directly affected by exogenous melatonin, rats received either melatonin or saline injections 15 min before administration of 2-deoxy-[1-14C]glucose (2-DG) at two times of day, circadian time (CT) 10 and CT14, and the brains of these rats were processed for autoradiographic determination of 2-DG uptake within the SCN. We report that SCN 2-DG uptake was inhibited by melatonin at CT10, when 2-DG uptake is normally high, and unaffected at CT14, when 2-DG uptake is normally low. This indicates that the SCN may be neural substrates through which melatonin exerts at least some of its effects on mammalian physiology.

AB - The pineal hormone melatonin has been implicated in the regulation of circadian rhythms and in photoperiodic control of reproduction. The effects of melatonin require the hypothalamic suprachiasmatic nucleus (SCN), a principal pacemaker controlling circadian rhythms. To determine whether SCN activity was directly affected by exogenous melatonin, rats received either melatonin or saline injections 15 min before administration of 2-deoxy-[1-14C]glucose (2-DG) at two times of day, circadian time (CT) 10 and CT14, and the brains of these rats were processed for autoradiographic determination of 2-DG uptake within the SCN. We report that SCN 2-DG uptake was inhibited by melatonin at CT10, when 2-DG uptake is normally high, and unaffected at CT14, when 2-DG uptake is normally low. This indicates that the SCN may be neural substrates through which melatonin exerts at least some of its effects on mammalian physiology.

KW - Circadian rhythm

KW - Melatonin

KW - Pineal gland

KW - Suprachiasmatic nucleus

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JO - Neuroscience Letters

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Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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