Melatonin receptors are for the birds: Molecular analysis of two receptor subtypes differentially expressed in chick brain

Steven M. Reppert, David R. Weaver, Vincent M. Cassone, Catherine Godson, Lee F. Kolakowski

Research output: Contribution to journalArticlepeer-review

315 Scopus citations

Abstract

Two receptors (CKA and CKB) of the G protein-coupled melatonin receptor family were cloned from chick brain. CKA encodes a protein that is 80% identical at the amino acid level to the human Mel1a melatonin receptor and is thus designated the chick Mel1a melatonin receptor. CKB encodes a protein that is 80% identical to the Xenopus melatonin receptor and defines a new receptor subtype, the Mel1c melatonin receptor, which is distinct from the Mel1a and Mel1b melatonin receptor subtypes. A melatonin receptor family consisting of three subtypes is supported by PCR cloning of distinct melatonin receptor fragments from Xenopus and zebrafish. Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds.

Original languageEnglish
Pages (from-to)1003-1015
Number of pages13
JournalNeuron
Volume15
Issue number5
DOIs
StatePublished - Nov 1995

Bibliographical note

Funding Information:
Two receptors (CKA and CKB) of the G protein-coupled melatonin receptor family were cloned from chick brain. CKA encodes a protein that is 80% identical at the amino acid level to the human Melt. melatonin receptor and is thus designated the chick Mella melatonin receptor. CKB encodes a protein that is 80% identical to the Xenopus melatonin receptor and defines a new receptor subtype, the Mellc melatonin receptor, which is distinct from the Mella and Mel~b melatonin receptor subtypes. A melatonin receptor family consisting of three subtypes is supported by PCR cloning of distinct melatonin receptor fragments from Xenopus and zebrafish. Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds.

ASJC Scopus subject areas

  • Neuroscience (all)

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