Memory interfering effects of chlordiazepoxide on consummatory successive negative contrast

Leonardo A. Ortega, Amanda C. Glueck, Alan M. Daniel, Mayerli A. Prado-Rivera, Michelle M. White, Mauricio R. Papini

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Long-Evans rats downshifted from 32% to 4% sucrose solution exhibit lower consummatory behavior during downshift trials than rats exposed only to 4% sucrose. In Experiment 1, this effect, called consummatory successive negative contrast (cSNC), was attenuated by administration of the benzodiazepine anxiolytic chlordiazepoxide (CDP, 5 mg/kg, ip) before the second downshift trial (Trial 12), but was not affected when CDP was administered before the first downshift trial (Trial 11). In Experiment 2, CDP administered after Trial 11 actually enhanced the cSNC effect on Trial 12. This posttrial effect of CDP was reduced by delayed administration (Experiment 3). This CDP effect was not present in the absence of incentive downshift (Experiments 4-5), or when animals were tested with the preshift incentive (Experiment 6) or after complete recovery from cSNC (Experiment 7). The posttrial CDP effect was observed after an 8-day interval between Trials 11 and 12 (Experiment 8) and when administered after Trial 12, rather than Trial 11 (Experiment 9). Experiment 10 extended the effect to Wistar rats. Because CDP is a memory interfering drug, it was hypothesized that its posttrial administration interferes with the consolidation of the memory of the downshifted incentive, thus prolonging the mismatch between expected (32% sucrose) and obtained (4% sucrose) incentives that leads to the cSNC effect.

Original languageEnglish
Pages (from-to)96-106
Number of pages11
JournalPharmacology Biochemistry and Behavior
StatePublished - Jan 2014

Bibliographical note

Funding Information:
The authors thank Carmen Torres for her valuable comments on an earlier version of this manuscript. The research reported in this article was carried out with IACUC approval in research facilities approved by the USDA. Support for this research was provided by SERC grants # 80104 and 90110 . Correspondence about this article may be sent to M. R. Papini ( ).


  • Allocentric memory
  • Chlordiazepoxide
  • Egocentric memory
  • Memory consolidation
  • Memory reconsolidation
  • Successive negative contrast

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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