Mesenteric vein L-glycine infusion alters splanchnic amino acid metabolism in steers

C. K. Reynolds, S. A. Maltby, D. L. Harmon, R. L. Prior

Research output: Contribution to journalArticlepeer-review


Effects of increased absorption of L-glycine on portal-drained visceral (PDV) and liver metabolism of plasma amino acids (AA) was measured m 6 multicatheterized beef steers (550 kg wt) fed 12 times/d 75% alfalfa:25% concentrate at 523 kj ME/kg wt75. Six hourly measurements of net AA flux (mmol/h) were made immediately before beginning and ending a 48 h mesentenc vein L-glycme infusion (25 mmol/h). Net flux is blood plasma flow times venous-arterial difference. Glycine infusion increased (P<.01) both PDV release (5.6 vs 31.4) and liver removal (0.1 vs 31.6) of glycine. In addition, net PDV release of serine (6.9 vs 9.1), asparagine (1.8 vs 3.8), threonine (3.8 vs 7.3), nonessential AA (34.6 vs 78.6) and total AA (63.8 vs 120.0) and net liver removal of alanîne (10.3 vs 17.4), tyrosine (3.3 vs 4.9), nonessential AA (18.4 vs 67.3), essential AA (0.9 vs 17.5) and total AA (19.2 vs 84.8) were increased (P<.10) by glycine infusion. Liver release of glutamate (19.1 vs 12.6) decreased (P<.03) when glycine was infused. Reasons for the increase in PDV release and liver removal of other AA during glycine infusion are uncertain. While there was no effect of glycine infusion on liver urea or glucose release (reported previously), there are numerous routes for glycine metabolism in the liver not measured in this study.

Original languageEnglish
Pages (from-to)A514
JournalFASEB Journal
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Mesenteric vein L-glycine infusion alters splanchnic amino acid metabolism in steers'. Together they form a unique fingerprint.

Cite this