Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China

Yuan Yuan Wang; Yu Jin; Chang Chen; Wei Zheng; Shi Bin Wang; Gabor S. Ungvari; Chee H. Ng; Xiaohua Douglas Zhang; Gang Wang; Yu Tao Xiang

doi:10.1080/09540121.2018.1554238

Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China

Yuan Yuan Wang, Yu Jin, Chang Chen, Wei Zheng, Shi Bin Wang, Gabor S. Ungvari, Chee H. Ng, Xiaohua Douglas Zhang, Gang Wang, Yu Tao Xiang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence (≥ 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of ≥ 95% adherence to HAART was 81.1% (95%CI: 75.1%–88.0%, I² = 97.3%) at one week, 80.9% (95%CI: 74.7%–85.9%, I² = 96.6%) at one month, and 68.3% (95%CI: 46.1%–84.4%, I² = 97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.

Original language	English
Pages (from-to)	913-922
Number of pages	10
Journal	AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume	31
Issue number	8
DOIs	https://doi.org/10.1080/09540121.2018.1554238
State	Published - Aug 3 2019

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Funding

This work was supported by Beijing Municipal Administration of Hospitals’ Ascent Plan [grant number DFL20151801]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [grant number ZYLX201607]; National Key Research & Development Program of China: [grant number 2016YFC1307200]; University of Macau: [grant number MYRG2015-00230-FHS; MYRG2016-00005-FHS].

Funders	Funder number
Beijing Municipal Administration of Hospitals’ Ascent Plan	DFL20151801
Universidade de Macau	MYRG2015-00230-FHS, MYRG2016-00005-FHS
Universidade de Macau
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support	ZYLX201607
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
National Key Basic Research and Development Program of China	2016YFC1307200
National Key Basic Research and Development Program of China

Keywords

China
HIV
cross-sectional studies
highly active antiretroviral therapy
meta-analysis

ASJC Scopus subject areas

Health(social science)
Social Psychology
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/09540121.2018.1554238

Cite this

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title = "Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China",

abstract = "With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence (≥ 95\%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of ≥ 95\% adherence to HAART was 81.1\% (95\%CI: 75.1\%–88.0\%, I2 = 97.3\%) at one week, 80.9\% (95\%CI: 74.7\%–85.9\%, I2 = 96.6\%) at one month, and 68.3\% (95\%CI: 46.1\%–84.4\%, I2 = 97.1\%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.",

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AU - Jin, Yu

AU - Chen, Chang

AU - Zheng, Wei

AU - Wang, Shi Bin

AU - Ungvari, Gabor S.

AU - Ng, Chee H.

AU - Zhang, Xiaohua Douglas

AU - Wang, Gang

AU - Xiang, Yu Tao

PY - 2019/8/3

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AB - With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence (≥ 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of ≥ 95% adherence to HAART was 81.1% (95%CI: 75.1%–88.0%, I2 = 97.3%) at one week, 80.9% (95%CI: 74.7%–85.9%, I2 = 96.6%) at one month, and 68.3% (95%CI: 46.1%–84.4%, I2 = 97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.

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KW - HIV

KW - cross-sectional studies

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KW - meta-analysis

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ER -

Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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