TY - JOUR
T1 - Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis
AU - Zwischenberger, Brittany A.
AU - Beasley, Mary M.
AU - Davenport, Daniel L.
AU - Xenos, Eleftherios S.
PY - 2013/11
Y1 - 2013/11
N2 - Purpose: To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS). Materials and Methods: A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls. Results: In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I2 = 18, P =.279). Conclusions: The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.
AB - Purpose: To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS). Materials and Methods: A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls. Results: In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I2 = 18, P =.279). Conclusions: The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.
KW - central nervous system
KW - chronic cerebrospinal venous insufficiency
KW - color Doppler
KW - multiple sclerosis
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U2 - 10.1177/1538574413503562
DO - 10.1177/1538574413503562
M3 - Article
C2 - 24005191
AN - SCOPUS:84887867203
SN - 1538-5744
VL - 47
SP - 620
EP - 624
JO - Vascular and Endovascular Surgery
JF - Vascular and Endovascular Surgery
IS - 8
ER -