Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

Milan Bera; Atanu Modak; Tuhin Patra; Arun Maji; Debabrata Maiti

doi:10.1021/ol502823c

Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

Milan Bera, Atanu Modak, Tuhin Patra, Arun Maji, Debabrata Maiti

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

Original language	English
Pages (from-to)	5760-5763
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	21
DOIs	https://doi.org/10.1021/ol502823c
State	Published - Nov 7 2014

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol502823c

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title = "Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group",

abstract = "A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.",

author = "Milan Bera and Atanu Modak and Tuhin Patra and Arun Maji and Debabrata Maiti",

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AU - Bera, Milan

AU - Modak, Atanu

AU - Patra, Tuhin

AU - Maji, Arun

AU - Maiti, Debabrata

PY - 2014/11/7

Y1 - 2014/11/7

N2 - A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

AB - A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

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DO - 10.1021/ol502823c

M3 - Article

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JF - Organic Letters

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ER -

Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

Abstract

Bibliographical note

ASJC Scopus subject areas

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