Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.
|Number of pages||3|
|State||Published - 2009|
Bibliographical noteFunding Information:
Acknowledgments This work was supported by Kentucky Challenge for Excellence; National Science Foundation/EPSCoR program.
- Balanced equation
- Lactic acidosis
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry