Metabolic acidosis and the importance of balanced equations

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
Issue number2
StatePublished - 2009

Bibliographical note

Funding Information:
Acknowledgments This work was supported by Kentucky Challenge for Excellence; National Science Foundation/EPSCoR program.


  • Balanced equation
  • Lactic acidosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry


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