Metabolic acidosis and the importance of balanced equations

Andrew N. Lane; Teresa W.M. Fan; Richard M. Higashi

doi:10.1007/s11306-008-0142-2

Metabolic acidosis and the importance of balanced equations

Andrew N. Lane, Teresa W.M. Fan, Richard M. Higashi

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.

Original language	English
Pages (from-to)	163-165
Number of pages	3
Journal	Metabolomics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s11306-008-0142-2
State	Published - 2009

Bibliographical note

Funding Information:
Acknowledgments This work was supported by Kentucky Challenge for Excellence; National Science Foundation/EPSCoR program.

Funding

Acknowledgments This work was supported by Kentucky Challenge for Excellence; National Science Foundation/EPSCoR program.

Funders	Funder number
Kentucky Challenge for Excellence
Kentucky National Science Foundation EPSCoR program

Keywords

Balanced equation
Lactic acidosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11306-008-0142-2

Cite this

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abstract = "Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.",

keywords = "Balanced equation, Lactic acidosis",

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AU - Lane, Andrew N.

AU - Fan, Teresa W.M.

AU - Higashi, Richard M.

N1 - Funding Information: Acknowledgments This work was supported by Kentucky Challenge for Excellence; National Science Foundation/EPSCoR program.

PY - 2009

Y1 - 2009

N2 - Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.

AB - Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.

KW - Balanced equation

KW - Lactic acidosis

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JO - Metabolomics

JF - Metabolomics

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ER -

Metabolic acidosis and the importance of balanced equations

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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