Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

David Allan Butterfield, Maria Favia, Iolanda Spera, Annalisa Campanella, Martina Lanza, Alessandra Castegna

Research output: Contribution to journalReview articlepeer-review

9 Citations (SciVal)

Abstract

Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

Original languageEnglish
Article number951
JournalMolecules
Volume27
Issue number3
DOIs
StatePublished - Feb 1 2022

Bibliographical note

Funding Information:
This research was funded in part by the National Institute of Aging, NIH [AG060056] (D.A.B.).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • AD
  • Alzheimer’s disease
  • Glucose
  • Metabolic reprogramming
  • Neurodegeneration
  • Oxidative stress
  • PD brain metabolism
  • Parkinson’s disease

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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