Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

David Allan Butterfield; Maria Favia; Iolanda Spera; Annalisa Campanella; Martina Lanza; Alessandra Castegna

doi:10.3390/molecules27030951

Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

David Allan Butterfield, Maria Favia, Iolanda Spera, Annalisa Campanella, Martina Lanza, Alessandra Castegna

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

Original language	English
Article number	951
Journal	Molecules
Volume	27
Issue number	3
DOIs	https://doi.org/10.3390/molecules27030951
State	Published - Feb 1 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

This research was funded in part by the National Institute of Aging, NIH [AG060056] (D.A.B.).

Funders	Funder number
National Institute on Aging
UK Industrial Decarbonization Research and Innovation Centre	104816
National Institutes of Health (NIH)	AG060056

Keywords

AD
Alzheimer’s disease
Glucose
Metabolic reprogramming
Neurodegeneration
Oxidative stress
PD brain metabolism
Parkinson’s disease

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules27030951

Cite this

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title = "Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases",

abstract = "Brain metabolism is comprised in Alzheimer{\textquoteright}s disease (AD) and Parkinson{\textquoteright}s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.",

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AU - Butterfield, David Allan

AU - Favia, Maria

AU - Spera, Iolanda

AU - Campanella, Annalisa

AU - Lanza, Martina

AU - Castegna, Alessandra

PY - 2022/2/1

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N2 - Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

AB - Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

KW - AD

KW - Alzheimer’s disease

KW - Glucose

KW - Metabolic reprogramming

KW - Neurodegeneration

KW - Oxidative stress

KW - PD brain metabolism

KW - Parkinson’s disease

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Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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