Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

David Allan Butterfield; Maria Favia; Iolanda Spera; Annalisa Campanella; Martina Lanza; Alessandra Castegna

doi:10.3390/molecules27030951

Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

David Allan Butterfield, Maria Favia, Iolanda Spera, Annalisa Campanella, Martina Lanza, Alessandra Castegna

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

Original language	English
Article number	951
Journal	Molecules
Volume	27
Issue number	3
DOIs	https://doi.org/10.3390/molecules27030951
State	Published - Feb 1 2022

Bibliographical note

Funding Information:
This research was funded in part by the National Institute of Aging, NIH [AG060056] (D.A.B.).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

AD
Alzheimer’s disease
Glucose
Metabolic reprogramming
Neurodegeneration
Oxidative stress
PD brain metabolism
Parkinson’s disease

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.3390/molecules27030951

Cite this

@article{38d25e01ed5243d9923df6fba565f2e8,

title = "Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases",

abstract = "Brain metabolism is comprised in Alzheimer{\textquoteright}s disease (AD) and Parkinson{\textquoteright}s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.",

keywords = "AD, Alzheimer{\textquoteright}s disease, Glucose, Metabolic reprogramming, Neurodegeneration, Oxidative stress, PD brain metabolism, Parkinson{\textquoteright}s disease",

author = "Butterfield, {David Allan} and Maria Favia and Iolanda Spera and Annalisa Campanella and Martina Lanza and Alessandra Castegna",

note = "Funding Information: This research was funded in part by the National Institute of Aging, NIH [AG060056] (D.A.B.). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/molecules27030951",

language = "English",

volume = "27",

number = "3",

}

TY - JOUR

T1 - Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

AU - Butterfield, David Allan

AU - Favia, Maria

AU - Spera, Iolanda

AU - Campanella, Annalisa

AU - Lanza, Martina

AU - Castegna, Alessandra

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

AB - Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

KW - AD

KW - Alzheimer’s disease

KW - Glucose

KW - Metabolic reprogramming

KW - Neurodegeneration

KW - Oxidative stress

KW - PD brain metabolism

KW - Parkinson’s disease

UR - http://www.scopus.com/inward/record.url?scp=85124277181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124277181&partnerID=8YFLogxK

U2 - 10.3390/molecules27030951

DO - 10.3390/molecules27030951

M3 - Review article

C2 - 35164216

AN - SCOPUS:85124277181

VL - 27

IS - 3

M1 - 951

ER -

Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this