Abstract
Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.
Original language | English |
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Article number | 951 |
Journal | Molecules |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2022 |
Bibliographical note
Publisher Copyright:© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Funding
This research was funded in part by the National Institute of Aging, NIH [AG060056] (D.A.B.).
Funders | Funder number |
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National Institute on Aging | |
UK Industrial Decarbonization Research and Innovation Centre | 104816 |
National Institutes of Health (NIH) | AG060056 |
Keywords
- AD
- Alzheimer’s disease
- Glucose
- Metabolic reprogramming
- Neurodegeneration
- Oxidative stress
- PD brain metabolism
- Parkinson’s disease
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry